5-chloro-1H-indole-2,3-dione → 5-Chloro-3-hydroxy-3-(3,5-dimethoxyphenyl)-1,3-dihydro-2H-indol-2-one

HRID 31349

Reaktionsgleichung

Reaktionsgleichung von HRID 31349
[Mg].Br[C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[C:5]([O:11][CH3:12])[CH:4]=1.[Cl:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18](=[O:23])[C:17]2=[O:24]>C1COCC1>[Cl:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18](=[O:23])[C:17]2([OH:24])[C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[C:5]([O:11][CH3:12])[CH:4]=1

Komponenten

5

Edukt 3

HCID 872035-chloro-1H-indole-2,3-dioneHCID 6391871-Bromo-3,5-dimethoxybenzeneHCID 5462224Magnesium

Produkt 1

HCID 225609115-Chloro-3-hydroxy-3-(3,5-dimethoxyphenyl)-1,3-dihydro-2H-indol-2-oneAusbeute 60,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

This compound is prepared according to the procedure described in step A of Preparation 1.6, starting with 1.2 g of magnesium, 9.5 g of 1-bromo-3,5-dimethoxybenzene, 50 ml of THF and a solution of 3 g of 5-chloro-1H-indole-2,3-dione in 50 ml of THF. 3.2 g of the expected product are obtained after crystallization from iso ether; m.p.=191° C.

Aufarbeitung

  1. customThis compound is prepared
  2. customdescribed in step A of Preparation 1.6

Quellen und Nachweise

ORD-Eintrag
ord-b91722a6d23c4616a697ac482eb50a9d
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07425566B2

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