Benzoyl chloride → 3-cyano-N-[4-(benzoylamino)-benzyl]-benzamide

HRID 31499Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 31499
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]([C:12]1[CH:13]=[C:14]([CH:26]=[CH:27][CH:28]=1)[C:15]([NH:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=1)=[O:16])#[N:11].C(N(CC)CC)C>C(Cl)Cl>[C:10]([C:12]1[CH:13]=[C:14]([CH:26]=[CH:27][CH:28]=1)[C:15]([NH:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:21][CH:20]=1)=[O:16])#[N:11]

Komponenten

5

Edukt 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 608931683-cyano-N-(4-amino-benzyl)-benzamide

Produkt 1

HCID 693086213-cyano-N-[4-(benzoylamino)-benzyl]-benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A solution of 0.6 g (4.2 mmol) of benzoylchloride in 10 ml of methylene chloride is added dropwise to a solution of 1 g (4 mmol) of 3-cyano-N-(4-amino-benzyl)-benzamide and 0.6 g (6 mmol) of triethylamine in 30 ml of methylene chloride at ambient temperature. After 8 hours at ambient temperature the product which has crystallised out is dissolved in methylene chloride and methanol. After extraction with water the combined organic extracts are dried and evaporated down.

Aufarbeitung

  1. customAfter 8 hours at ambient temperature the product which has crystallised out
  2. dissolutionis dissolved in methylene chloride
  3. extractionAfter extraction with water the combined organic extracts
  4. customare dried
  5. customevaporated down

Quellen und Nachweise

ORD-Eintrag
ord-2bed51339cdf4881b929757cb7991d35
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07425641B2

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