Methylamine → 6-chloro-N-methyl-3-nitropyridin-2-amine

Reaktionsgleichung

[Cl:1][C:2]1[N:7]=[C:6]([N:8](C)[CH3:9])[C:5]([N+:11]([O-:13])=[O:12])=[CH:4][CH:3]=1.CN>>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH3:9])[C:5]([N+:11]([O-:13])=[O:12])=[CH:4][CH:3]=1

Komponenten

Edukt 2

HCID 6329Methylamine

HCID 217876256-Chloro-2-dimethylamino-3-nitropyridine

Produkt 1

HCID 107500946-chloro-N-methyl-3-nitropyridin-2-amine

Versuchsvorschrift

6-chloro-2-methylamino-3-nitro-pyridine was prepared in accordance to the procedure described above for the preparation of 6-chloro-2-dimethylamino-3-nitro pyridine by using solution of methyl amine. The crude product was purified by flash chromatography, eluting with 90% hexane: 10% ethyl acetate to 16 (300 mg).

Aufarbeitung

customThe crude product was purified by flash chromatography
washeluting with 90% hexane

Quellen und Nachweise

ORD-Eintrag: ord-28a6a2630152406486bf79fccdaebfea
Quelldatensatz: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07425557B2

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