Toluene → 1-Nitro-2-(3,3,4,4-tetramethylcyclopent-1-enyl)benzene

HRID 32168

Reaktionsgleichung

Reaktionsgleichung von HRID 32168
[CH3:1][C:2]1([CH3:17])[C:6]([CH3:8])([CH3:7])[CH2:5][C:4](OS(C(F)(F)F)(=O)=O)=[CH:3]1.[N+:18]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1B(O)O)([O-:20])=[O:19].C(=O)([O-])[O-].[Na+].[Na+].C1(C)C=CC=CC=1>[Cl-].[Na+].O.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(OCC)(=O)C.C(O)C>[N+:18]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:4]1[CH2:5][C:6]([CH3:8])([CH3:7])[C:2]([CH3:17])([CH3:1])[CH:3]=1)([O-:20])=[O:19]

Komponenten

9

Edukt 4

HCID 1140TolueneHCID 10340Sodium CarbonateHCID 2773548(2-Nitrophenyl)boronic acidHCID 59769424Trifluoromethanesulfonic acid 3,3,4,4-tetramethylcyclopent-1-enyl ester

Produkt 1

HCID 231417801-Nitro-2-(3,3,4,4-tetramethylcyclopent-1-enyl)benzeneAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 178418397HCID 178418397, VerbindungKatalysatorHCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittelHCID 57417360Sodium chloride; waterLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A mixture of the trifluoromethanesulfonic acid 3,3,4,4-tetramethylcyclopent-1-enyl ester (992 mg, 3.64 mmol) produced in Example (54a), 2-nitrophenylboronic acid (729 mg, 4.37 mmol), tetrakis(triphenylphosphine)palladium(0) (219 mg, 0.189 mmol), 2N aqueous solution of sodium carbonate (3.64 mL), toluene (12.5 mL) and ethanol (6.3 mL) was stirred for 6 hours at an external temperature of 90° C. under a nitrogen atmosphere. The reaction mixture was air-cooled to room temperature, and then ethyl acetate and brine were added and extraction was performed twice with ethyl acetate. The separated organic layer was dried over anhydrous sodium sulfate. The desiccant was filtered off and the filtrate was concentrated under reduced pressure. The resultant residue was purified by silica gel column chromatography (ethyl acetate/heptane) to give 891 mg of the title compound as a light brown oil.

Aufarbeitung

  1. temperatureThe reaction mixture was air-cooled to room temperature
  2. extractionextraction
  3. dry with materialThe separated organic layer was dried over anhydrous sodium sulfate
  4. filtrationThe desiccant was filtered off
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. customThe resultant residue was purified by silica gel column chromatography (ethyl acetate/heptane)

Quellen und Nachweise

ORD-Eintrag
ord-9d1ee1ce6ed44d579d2fffaef459ebe4
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07425554B2

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