Thionyl Chloride → 4-(Trifluoromethyl)cinnamoyl chloride

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

200.0 mg (0.92 mmol) of trans-4-trifluoromethylcinnamic acid were treated with 200 μl of thionyl chloride. After addition of 2 drops of DMF, the reaction solution obtained was stirred at 75° C. for 3 h. It was then concentrated to dryness, and the residue was taken up in toluene 2× and concentrated to dryness again. Drying in a high vacuum yielded 237.0 mg of the title compound as a slightly yellow, amorphous powder.

Herkunft & Nachweise