1-[4-(4-Benzyloxyphenyl)butyl]-1,2,4-triazole → 1-[4-(4-Hydroxyphenyl)butyl]-1,2,4-triazole

HRID 322256Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 322256
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[CH:23]=[N:22][CH:21]=[N:20]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>[C].[Pd].C(O)C>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[CH:23]=[N:22][CH:21]=[N:20]2)=[CH:11][CH:10]=1

Komponenten

4

Edukt 1

HCID 220098341-[4-(4-Benzyloxyphenyl)butyl]-1,2,4-triazole

Produkt 1

HCID 220096301-[4-(4-Hydroxyphenyl)butyl]-1,2,4-triazoleAusbeute 55 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 1-[4-(4-benzyloxyphenyl)butyl]-1,2,4-triazole (3.15 g), palladium-carbon (5%, 3.0 g) and ethanol (50 ml) was subjected to catalytic hydrogenation under atmospheric pressure at room temperature. The catalyst was filtered off, and the filtrate was concentrated. The residue was subjected to a silica gel column chromatography. The crystalline product obtained from the fraction eluted with tetrahydrofuran-hexane (1:1, v/v) was recrystallized from ethyl acetate-hexane to give 1-[4-(4-hydroxyphenyl)butyl]-1,2,4-triazole (1.22 g, 55%) as colorless prisms, mp 135-136° C.

Aufarbeitung

  1. customwas subjected to catalytic hydrogenation under atmospheric pressure at room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated
  4. customThe crystalline product obtained from the fraction
  5. washeluted with tetrahydrofuran-hexane (1:1
  6. customv/v) was recrystallized from ethyl acetate-hexane

Quellen und Nachweise

ORD-Eintrag
ord-48e1fa762fb7461fb53c2c44b99a5ac7
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211215B1

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