1,3-Dichloroacetone → 6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine

HRID 322294

Reaktionsgleichung

Reaktionsgleichung von HRID 322294
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[Cl:9][CH2:10][C:11]([CH2:13]Cl)=O>COCCOC>[Br:8][C:5]1[CH:6]=[CH:7][C:2]2[N:3]([CH:13]=[C:11]([CH2:10][Cl:9])[N:1]=2)[CH:4]=1

Komponenten

4

Edukt 2

HCID 107931,3-DichloroacetoneHCID 706222-Amino-5-bromopyridine

Produkt 1

HCID 116228946-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridineAusbeute 10,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80711,2-DimethoxyethaneLösungsmittel

Versuchsvorschrift

A mixture of 2-amino-5-bromopyridine (10.0 g). 1,3-dichloroacetone (7.71 g) and 1,2-dimethoxyethane (40 ml) was stirred at room temperature for 4 hours. The precipitated crystals were collected by filtration, to which ethanol (100 ml) was added and heated under reflux. The reaction mixture was concentrated, diluted with saturated aqueous sodium bicarbonate, and extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried (MgSO4), and concentrated under reduced pressure to give crystals of 6-bromo-2-chloromethylimidazo-[1,2-a]pyridine (1.48 g, 10%). Recrystallization from ethyl acetate-hexane gave colorless needles, mp 129-130° C.

Aufarbeitung

  1. filtrationThe precipitated crystals were collected by filtration, to which ethanol (100 ml)
  2. additionwas added
  3. temperatureheated
  4. temperatureunder reflux
  5. concentrationThe reaction mixture was concentrated
  6. additiondiluted with saturated aqueous sodium bicarbonate
  7. extractionextracted with ethyl acetate
  8. washThe ethyl acetate layer was washed with water
  9. dry with materialdried (MgSO4)
  10. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-fb4cf1708f384c6ea2674a91b781cbde
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211215B1

Verknüpfte Notizen

Wird geladen…