1,3-Dichloroacetone → 4-Chloromethyl-2-(2-thienylmethyl)oxazole
Reaktionsgleichung
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH2:9])=[O:8].[Cl:10][CH2:11][C:12]([CH2:14]Cl)=O>>[Cl:10][CH2:11][C:12]1[N:9]=[C:7]([CH2:6][C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)[O:8][CH:14]=1Komponenten
3
Versuchsvorschrift
In substantially the same manner as in Reference Example 47, 2-thiopheneacetamide was reacted with 1,3-dichloroacetone to give 4-chloromethyl-2-(2-thienylmethyl)oxazole. The yield was 27%. Oily substance.
Quellen und Nachweise
- ORD-Eintrag
- ord-e576de2d248e4d1ab3eaf0e7d641e0ad
- Quelldatensatz
- uspto-grants-2001_04
- Patentnummer
- US06211215B1
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