1H-Imidazole-4,5-dicarboxylic acid, 4,5-dimethyl ester → HCID 22009793, Verbindung

HRID 322365

Reaktionsgleichung

Reaktionsgleichung von HRID 322365
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[N:18]=[C:19](/[CH:22]=[CH:23]/[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[O:20][CH:21]=2)=[CH:11][CH:10]=1)(=O)=O.[NH:30]1[C:34]([C:35]([O:37][CH3:38])=[O:36])=[C:33]([C:39]([O:41][CH3:42])=[O:40])[N:32]=[CH:31]1>>[C:24]1(/[CH:23]=[CH:22]/[C:19]2[O:20][CH:21]=[C:17]([CH2:16][O:15][C:12]3[CH:11]=[CH:10][C:9]([CH2:8][CH2:7][CH2:6][N:30]4[C:34]([C:35]([O:37][CH3:38])=[O:36])=[C:33]([C:39]([O:41][CH3:42])=[O:40])[N:32]=[CH:31]4)=[CH:14][CH:13]=3)[N:18]=2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Komponenten

3

Edukt 2

HCID 768101H-Imidazole-4,5-dicarboxylic acid, 4,5-dimethyl esterHCID 155216743-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate

Produkt 1

HCID 22009793HCID 22009793, VerbindungAusbeute 63 %

Versuchsvorschrift

In substantially the same manner as in Working Example 25, 3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate was allowed to react with dimethyl 4,5-imidazoledicarboxylate to give dimethyl 1-[3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl]-4,5-imidazoledicarboxylate. The yield was 63%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 85-86° C.

Quellen und Nachweise

ORD-Eintrag
ord-d87845049e87477280fe9d4fbf2d9808
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211215B1

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