HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-(Chloromethyl)-2-phenyl-1,3-oxazole → 4-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-phenyloxazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-(Chloromethyl)-2-phenyl-1,3-oxazole | HCID 3551196 | — |
| Edukt | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| Produkt | 4-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-phenyloxazole | HCID 22009806 | 42% |
Reaktionsschritte
In substantially the same manner as in Working Example 37, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-phenyloxazole to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-phenyloxazole. The yield was 42%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 111-112° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06211215B1 |
| Quelldatensatz | uspto-grants-2001_04 |
| ORD ID | ord-f60c9f794dd54cc2b32dd8e0cee4fea1 |
| Quellennotiz | uspto-grants-2001_04 |