4-[4-(Chloromethyl)-1,3-oxazol-2-yl]benzonitrile → 2-(4-Cyanophenyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole
Reaktionsgleichung
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[N:19]=[C:20]([C:23]2[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][CH:24]=2)[O:21][CH:22]=1>>[C:29]([C:26]1[CH:25]=[CH:24][C:23]([C:20]2[O:21][CH:22]=[C:18]([CH2:17][O:1][C:2]3[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]4[CH:15]=[CH:14][N:13]=[CH:12]4)=[CH:4][CH:3]=3)[N:19]=2)=[CH:28][CH:27]=1)#[N:30]Komponenten
3
Versuchsvorschrift
In substantially the same manner as in Working Example 48, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(4-cyanophenyl) oxazole to give 2-(4-cyanophenyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 72%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 98-99° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-e09ad938946c4f68b98837157f5cb6a1
- Quelldatensatz
- uspto-grants-2001_04
- Patentnummer
- US06211215B1
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