HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-[4-(3-Hydroxyphenyl)butyl]imidazole → 2-(4-Benzyloxyphenyl)-4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-[4-(3-Hydroxyphenyl)butyl]imidazole | HCID 22009661 | — |
| Edukt | 2-(4-Benzyloxy-phenyl)-4-chloromethyl-oxazole | HCID 22009845 | — |
| Produkt | 2-(4-Benzyloxyphenyl)-4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole | HCID 22009675 | 78% |
Reaktionsschritte
In substantially the same manner as in Working Example 72, 1-[4-(3-hydroxyphenyl)butyl]imidazole was allowed to react with 2-(4-benzyloxyphenyl)-4-chloromethyloxazole to give 2-(4-benzyloxyphenyl)-4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole. The yield was 78%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 87-88° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06211215B1 |
| Quelldatensatz | uspto-grants-2001_04 |
| ORD ID | ord-03c85665c5d446708c377b40e1b2cb77 |
| Quellennotiz | uspto-grants-2001_04 |