4-(Chloromethyl)-2-phenyl-1,3-thiazole → 4-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-phenylthiazole

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4-(Chloromethyl)-2-phenyl-1,3-thiazole	HCID 236969	—
Edukt	1-[3-(3-Hydroxyphenyl)propyl]imidazole	HCID 22009809	—
Produkt	4-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-phenylthiazole	HCID 22009596	81%

Reaktionsschritte

In substantially the same manner as in Working Example 72, 1-[3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-phenylthiazole to give 4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-phenylthiazole. The yield was 81%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 63-64° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06211215B1
Quelldatensatz	uspto-grants-2001_04
ORD ID	ord-a101a9a1a4ac440692d45f0865a967ea
Quellennotiz	uspto-grants-2001_04