HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(5-Bromo-4-methyl-2-thienyl)-4-chloromethyloxazole → 2-(5-Bromo-4-methyl-2-thienyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(5-Bromo-4-methyl-2-thienyl)-4-chloromethyloxazole | HCID 22009708 | — |
| Edukt | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| Produkt | 2-(5-Bromo-4-methyl-2-thienyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole | HCID 22009597 | 77% |
Reaktionsschritte
In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 2-(5-bromo-4-methyl-2-thienyl)-4-chloromethyloxazole to give 2-(5-bromo-4-methyl-2-thienyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 77%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 92-93° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06211215B1 |
| Quelldatensatz | uspto-grants-2001_04 |
| ORD ID | ord-f9c4970ae65b4b01a2e4dbac6d907b6e |
| Quellennotiz | uspto-grants-2001_04 |