3-(4-Methoxybenzylamino)-6-methyl-1-carboxymethyl pyrazinone → (3-Amino-6-methyl-2-oxopyrazin-1(2H)-YL)acetic acid

HRID 322547Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 322547
COC1C=CC(C[NH:8][C:9]2[C:10](=[O:20])[N:11]([CH2:16][C:17]([OH:19])=[O:18])[C:12]([CH3:15])=[CH:13][N:14]=2)=CC=1>FC(F)(F)C(O)=O>[NH2:8][C:9]1[C:10](=[O:20])[N:11]([CH2:16][C:17]([OH:19])=[O:18])[C:12]([CH3:15])=[CH:13][N:14]=1

Komponenten

3

Edukt 1

HCID 220087443-(4-Methoxybenzylamino)-6-methyl-1-carboxymethyl pyrazinone

Produkt 1

HCID 22008747(3-Amino-6-methyl-2-oxopyrazin-1(2H)-YL)acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

The pyrazinone 18-6 (900 mg) was heated at reflux in trifluoroacetic acid (20 mL) for 7 h. The volatiles were removed in vacuo and the residue was azeotroped with CH2Cl2, then EtOAc then MeOH. MeOH was added to the residue and the solution filtered to remove impurities. Removal of the methanol then afforded the title compound 18-7 which was used as such:

Aufarbeitung

  1. customThe volatiles were removed in vacuo
  2. customthe residue was azeotroped with CH2Cl2
  3. additionMeOH was added to the residue
  4. filtrationthe solution filtered
  5. customto remove impurities
  6. customRemoval of the methanol

Quellen und Nachweise

ORD-Eintrag
ord-8b4d4be21f104dcea21508ba435f4df0
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211184B1

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