Thionyl Chloride → 1-(2-Chloroethoxy)-4-nitrobenzene

HRID 322630

Reaktionsgleichung

Reaktionsgleichung von HRID 322630
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12]O)=[CH:6][CH:5]=1)([O-:3])=[O:2].S(Cl)([Cl:16])=O>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][Cl:16])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 853812-(4-Nitrophenoxy)ethanol

Produkt 1

HCID 27645871-(2-Chloroethoxy)-4-nitrobenzene

Versuchsvorschrift

4-Nitro-(2-Hydroxyethoxy)benzene (1.13 g, 6.2 mmol) in thionyl chloride (10 mL) is heated at reflux for 3 hours then concentrated in vacuo. After cooling the residue in an ice water bath, saturated aqueous sodium bicarbonate is added and the precipitate collected, rinsed with water, and dried to give 4-nitro-(2-chloroethoxy)benzene (909 mg).

Aufarbeitung

  1. temperatureat reflux for 3 hours
  2. concentrationthen concentrated in vacuo
  3. temperatureAfter cooling the residue in an ice water bath
  4. additionsaturated aqueous sodium bicarbonate is added
  5. customthe precipitate collected
  6. washrinsed with water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c4e1a6c1250a445185e50851c001f832
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211365B1

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