Reaktionsgleichung
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.Cl.[CH2:13]([O:17][C:18](=[O:22])[CH:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[CH:19]([CH3:21])[NH:20][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=1)[CH:14]([CH3:16])[CH3:15]Komponenten
3
Versuchsvorschrift
Following General Procedure B′ and using 4methylphenylacetic acid (Aldrich) and D,L-alanine isobutyl ester hydrochloride (from Example B′ above), the title compound was prepared as a solid having a melting point of 102°-104° C. The reaction was monitored by tlc on silica gel (Rf=0.6 in 33% ethyl acetate/hexanes) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.
Quellen und Nachweise
- ORD-Eintrag
- ord-465535fa819a4224bee6543aa6309387
- Quelldatensatz
- uspto-grants-2001_04
- Patentnummer
- US06211235B1
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