3,5-Difluorophenylacetic acid → N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester

HRID 322676

Reaktionsgleichung

Reaktionsgleichung von HRID 322676
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH:20][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=1)[CH:14]([CH3:16])[CH3:15]

Komponenten

3

Edukt 2

HCID 1454243,5-Difluorophenylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Produkt 1

HCID 22894975N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester

Versuchsvorschrift

Following General Procedure I′ above, and using 3,5-difluorophenylacetic acid (Aldrich) and alanine iso-butyl ester prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Aufarbeitung

  1. customprepared

Quellen und Nachweise

ORD-Eintrag
ord-99d28e85a23147c2a10d70f8dc79ecbd
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211235B1

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