HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Tyrosine Methyl Ester → N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-tyrosine Methyl Ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Tyrosine Methyl Ester | HCID 70652 | — |
| Edukt | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Produkt | N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-tyrosine Methyl Ester | HCID 10180420 | — |
Reaktionsschritte
Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and L-tyrosine methyl ester (Bachem), the title compound was prepared as a solid (mp=85-88° C.). The reaction was monitored by tlc (Rf=0.27 in 50% EtOAc/hexanes) and the product was purified by silica gel column chromatography.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06211235B1 |
| Quelldatensatz | uspto-grants-2001_04 |
| ORD ID | ord-31cb0ec84a4f45a19dd41a2fc74b8660 |
| Quellennotiz | uspto-grants-2001_04 |