Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate → Methyl 2-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-1,2,3,4tetrahydroisoquinoline-3-carboxylate

HRID 322716

Reaktionsgleichung

Reaktionsgleichung von HRID 322716
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH:20]([C:28]([O:30][CH3:31])=[O:29])[NH:19]1>CO.C(Cl)Cl>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([N:19]2[CH:20]([C:28]([O:30][CH3:31])=[O:29])[CH2:21][C:22]3[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:18]2)=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1

Komponenten

4

Edukt 2

HCID 4685119Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylateHCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid

Produkt 1

HCID 10158832Methyl 2-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-1,2,3,4tetrahydroisoquinoline-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21226129Dichloromethane methanolLösungsmittel

Versuchsvorschrift

Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate (Aldrich), the title compound was prepared as a solid (mp=37-40° C.). The reaction was monitored by tlc (Rf=0.64 in 10% MeOH/DCM).

Quellen und Nachweise

ORD-Eintrag
ord-dad013ff7cf5455ebaa374aeef3d31fa
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211235B1

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