Triethylamine → N-(1-Cyanocyclopentyl)pentanamide

HRID 322810

Reaktionsgleichung

Reaktionsgleichung von HRID 322810
[NH2:1][C:2]1([C:7]#[N:8])[CH2:6][CH2:5][CH2:4][CH2:3]1.C(N(CC)CC)C.[C:16](Cl)(=[O:21])[CH2:17][CH2:18][CH2:19][CH3:20]>ClCCl>[C:7]([C:2]1([NH:1][C:16](=[O:21])[CH2:17][CH2:18][CH2:19][CH3:20])[CH2:6][CH2:5][CH2:4][CH2:3]1)#[N:8]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 21068971-Aminocyclopentanecarbonitrile

Produkt 1

HCID 11790092N-(1-Cyanocyclopentyl)pentanamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
32.5 °C

Versuchsvorschrift

To 11.0 g (0.1 mol) of 1-amino-1-cyanocyclopentane dissolved in 100 ml of dichloromethane, 15 ml 10. g (0.1 mol) of triethylamine was added, then dropwise 13 ml, 13 g (0.1 mol) of valeroyl chloride, while keeping the temperature at 25-35° C. The reaction mixture was stirred at 30-35° C. for 2 hours, then it was washed with water. The phases were separated, the organic phase was evaporated to obtain the pure title compound as an oil. The compound was identified by elementary analysis, IR, NMR and GC-MS spectrometry.

Aufarbeitung

  1. customat 25-35° C
  2. washit was washed with water
  3. customThe phases were separated
  4. customthe organic phase was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-c955579b5894498eafbf043d733950c1
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211382B1

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