Sodium Hydroxide → HCID 10644171, Verbindung

HRID 322849Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 322849
[CH2:1]([O:8][C:9]1[CH:22]=[C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:20]=[CH:19][C:10]=1[C:11]([NH:13][CH2:14][C:15]([O:17]C)=[O:16])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[CH2:1]([O:8][C:9]1[CH:22]=[C:21]([O:23][CH2:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:20]=[CH:19][C:10]=1[C:11]([NH:13][CH2:14][C:15]([OH:17])=[O:16])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 10787454HCID 10787454, Verbindung

Produkt 1

HCID 10644171HCID 10644171, VerbindungAusbeute 34,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

A solution of methyl N-(2,4-dibenzyloxybenzoyl)glycinate (900 mg) in methanol (20 mL) is treated with 1 M NaOH (20 mL) and stirred at 25° C. for 2 hours. The solution is evaporated, the residue diluted with water, brought to pH 1 and extracted with ethyl acetate. The extract is dried and evaporated. The residue is recrystallized from methanol to yield N-(2,4-dibenzyloxybenzoyl)glycine as a colourless solid (300 mg), m.p. 183° C. H NMR (CDCl3) 4.15(2H,d), 5.05 (2H,s), 5.2(2H,s), 6.6(1H,s), 6.7(1H,d), 7.3-7.5(10H,m), 8.2(1H,d), 8.4(1H,t).

Aufarbeitung

  1. customThe solution is evaporated
  2. additionthe residue diluted with water
  3. extractionextracted with ethyl acetate
  4. customThe extract is dried
  5. customevaporated
  6. customThe residue is recrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-27d4c5d9c7774501a70696183c432364
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211234B1

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