Dichloromethane → N-(2-diethylamino-ethyl)-4-(methanesulfonylamino)-2-methoxy-benzamide

HRID 32291Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 32291
[CH2:1]([N:3]([CH2:26][CH3:27])[CH2:4][CH2:5][NH:6][C:7](=[O:25])[C:8]1[CH:13]=[CH:12][C:11]([N:14](S(C)(=O)=O)[S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][C:9]=1[O:23][CH3:24])[CH3:2].[OH-].[K+].C(=O)(O)[O-].[Na+].C(Cl)Cl>O1CCCC1>[CH2:26]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][NH:6][C:7](=[O:25])[C:8]1[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:16])=[O:17])=[CH:10][C:9]=1[O:23][CH3:24])[CH3:27]

Komponenten

6

Edukt 4

HCID 6344DichloromethaneHCID 14797Potassium HydroxideHCID 516892Sodium BicarbonateHCID 66934940N-(2-diethylamino-ethyl)-4-(bismethanesulfonylamino)-2-methoxy-benzamide

Produkt 1

HCID 16748090N-(2-diethylamino-ethyl)-4-(methanesulfonylamino)-2-methoxy-benzamideAusbeute 92,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

150 mg (0.36 mmol) of N-(2-diethylamino-ethyl)-4-(bismethanesulfonylamino)-2-methoxy-benzamide is dissolved in 10 ml of tetrahydrofuran and mixed with 1 ml of 1N potassium hydroxide solution. It is stirred for 2 hours at room temperature. Then, the tetrahydrofuran is drawn off in a vacuum, mixed with 25 ml of saturated sodium bicarbonate solution and shaken out three times with 25 ml each of methylene chloride. The collected organic phase is dried, filtered and concentrated by evaporation, and 114 mg (91.9% of theory) of N-(2-diethylamino-ethyl)-4-(methanesulfonylamino)-2-methoxy-benzamide is obtained.

Aufarbeitung

  1. customThe collected organic phase is dried
  2. filtrationfiltered
  3. concentrationconcentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-678bca9214434652ade6c26edceda413
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07427390B2

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