Piperazine → HCID 22010937, Verbindung

HRID 323137Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 323137
[N+:1]([C:4]1[CH:33]=[CH:32][C:7]([C:8]([N:10]([CH3:31])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]([O:24]C2C=CC=CC=2)=O)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1.[CH3:40]N(C)C=O>C(OCC)(=O)C>[N+:1]([C:4]1[CH:33]=[CH:32][C:7]([C:8]([N:10]([CH3:31])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]([N:34]2[CH2:39][CH2:38][N:37]([CH3:40])[CH2:36][CH2:35]2)=[O:24])=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Komponenten

5

Edukt 3

HCID 4837PiperazineHCID 6228DimethylformamideHCID 220105644-nitro-N-methyl-N-[2-(3-phenoxycarbonylaminoprop-1-yloxy)phenyl]benzamide

Produkt 1

HCID 22010937HCID 22010937, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 4-nitro-N-methyl-N-[2-(3-phenoxycarbonylaminoprop-1-yloxy)phenyl]benzamide (383 mg) and piperazine (256 mg) in N,N-dimethylformamide (8 ml) was stirred at 80° C. for 3 hours. The reaction mixture was diluted with ethyl acetate and then the organic solution was washed successively with saturated sodium bicarbonate aqueous solution and brine. Drying, filtering and removal of solvents afforded 4-nitro-N-methyl-N-[2-{3-(4-methyl-1-piperazinyl)carbonylaminoprop-1-yloxy}phenyl]benzamide (357 mg) as a slightly yellow oil.

Aufarbeitung

  1. washthe organic solution was washed successively with saturated sodium bicarbonate aqueous solution and brine
  2. customDrying
  3. filtrationfiltering
  4. customremoval of solvents

Quellen und Nachweise

ORD-Eintrag
ord-a3d31a6965364de9a8b4ed9347b47f78
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211242B1

Notizen zur Reaktion

Wird geladen…