Potassium Carbonate → HCID 22010926, Verbindung

HRID 323167Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 323167
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:14]([NH:16][C:17]3[CH:39]=[CH:38][C:20]([C:21]([N:23]([CH3:37])[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[O:30][CH2:31][CH2:32][O:33]C(=O)C)=[O:22])=[CH:19][CH:18]=3)=[O:15])=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO.C(OCC)(=O)C>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([C:14]([NH:16][C:17]3[CH:18]=[CH:19][C:20]([C:21]([N:23]([CH3:37])[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[O:30][CH2:31][CH2:32][OH:33])=[O:22])=[CH:38][CH:39]=3)=[O:15])=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 11430Potassium CarbonateHCID 22010642HCID 22010642, Verbindung

Produkt 1

HCID 22010926HCID 22010926, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-(2-acetoxyethoxy)phenyl]benzamide and potassium carbonate (129 mg) in methanol (15 ml) was stirred at ambient temperature for 2 hours and the mixture was diluted with ethyl acetate (30 ml). The solution was washed with water and brine and the organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-(2-hydroxyethoxy)phenyl]benzamide (450 mg) as an oil.

Aufarbeitung

  1. washThe solution was washed with water and brine
  2. dry with materialthe organic solution was dried over magnesium sulfate
  3. customthe solvent was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f6f2868a7619450d80804b138a0c7720
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211242B1

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