Potassium Hydroxide → 5-Mesyl-o-anisic acid

HRID 323395Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 323395
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[K+]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

Komponenten

3

Edukt 2

HCID 14797Potassium HydroxideHCID 6454622Methyl 5-mesyl-o-anisate

Produkt 1

HCID 1708405-Mesyl-o-anisic acid

Versuchsvorschrift

Combine methyl 2-methoxy-5-methylsulfonylbenzoate (2.24 g, 9.2 mmol) and a 1 M aqueous potassium hydroxide solution (10 mL, 10 mmol). Heat to reflux. After 2 hours, filter while still hot, cool in an ice bath, and acidify by dropwise addition of a 1 M aqueous hydrochloric acid solution (11 mL) to give a solid. Collect the solid by filtration, rinse with water, and dry to give the title compound.

Aufarbeitung

  1. temperatureHeat to reflux
  2. filtrationfilter while still hot,
  3. temperaturecool in an ice bath
  4. additionacidify by dropwise addition of a 1 M aqueous hydrochloric acid solution (11 mL)
  5. customto give a solid
  6. customCollect the solid
  7. filtrationby filtration
  8. washrinse with water
  9. customdry

Quellen und Nachweise

ORD-Eintrag
ord-51e6a8f6e2ec4f5b836d67b9f2ad5d02
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211199B1

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