3-Chloro-1H-indole-6-carboxylic acid → 4-{2-[(3-Chloro-1H-indole-6-carbonyl)amino]-2-(2-chloro-phenyl)ethoxymethyl}piperidine-1-carboxylic acid tert-butyl ester

Beteiligte Stoffe

Reaktionsschritte

Using coupling method A, 4-[2-amino-2-(2-chlorophenyl)-ethoxymethyl]piperidine-1-carboxylic acid tert-butyl ester (7.5 g, 20 mmol) and 3-chloroindole-6-carboxylic acid (3.9 g, 20 mmol) afforded, after purification (SiO2: 33% to 50% EtOAc in hexane), 8 g (73%) of the title compound.

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