HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetaldehyde → 3-Chloro-N-[1-(2-chlorophenyl)-2-(1-ethylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetaldehyde | HCID 177 | — |
| Edukt | 3-chloro-N-[1-(2-chlorophenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide | HCID 69307888 | — |
| Produkt | 3-Chloro-N-[1-(2-chlorophenyl)-2-(1-ethylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide | HCID 44444086 | — |
Reaktionsschritte
Using alkylation method A, 3-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (600 mg, 1.3 mmol) and acetaldehyde (0.4 mL, 6.7 mmol) afforded, after purification (SiO2: 10:10:1 hexane:EtOAc:isopropylamine) and recrystallization (acetonitrile), 275 mg (43%) of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07427632B2 |
| Quelldatensatz | uspto-grants-2008_09 |
| ORD ID | ord-17395d43aa494cd5984f29920228c68a |
| Quellennotiz | uspto-grants-2008_09 |