Trifluoroacetic acid → HCID 22004376, Verbindung

HRID 324348Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 324348
FC(F)(F)C(O)=O.C([O:12][C:13]([CH2:15][N:16]1[N:25]=[C:24]([NH:26][CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([Cl:36])[CH:29]=2)[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:37]#[N:38])[CH:22]=2)[C:17]1=[O:39])=[O:14])(C)(C)C>>[C:13]([CH2:15][N:16]1[N:25]=[C:24]([NH:26][CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([Cl:36])[CH:29]=2)[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:37]#[N:38])[CH:22]=2)[C:17]1=[O:39])([OH:14])=[O:12]

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 220043942-tert-Butoxycarbonylmethyl-4-(3-chloro-4-methoxybenzyl)amino-6-cyano-1(2H)-phthalazinone

Produkt 1

HCID 22004376HCID 22004376, VerbindungAusbeute 16,7 %

Versuchsvorschrift

Trifluoroacetic acid (5 ml) was added to 0.41 g of the t-butyl ester prepared in Example 22. The obtained mixture was stirred at room temperature for one hour and freed from the trifluoroacetic acid by vacuum distillation. The obtained residue was recrystallized from ethanol/water to give 0.06 g of the title compound as a yellow crystal.

Aufarbeitung

  1. distillationfreed from the trifluoroacetic acid by vacuum distillation
  2. customThe obtained residue was recrystallized from ethanol/water

Quellen und Nachweise

ORD-Eintrag
ord-d4148c6106ae4272ab77359f5e4d6c28
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06218392B1

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