Ethyl 2-(bromomethyl)-1,3-oxazole-4-carboxylate → (+/-)-2-[[5-(7-Ethyl-2-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-oxazolecarboxylic acid, ethyl ester

HRID 324412Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 324412
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]2[CH:16]([C:17]3[C:18](=[O:24])[NH:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:11]3[N:12]=[C:13]([CH3:15])[O:14][C:10]=3[CH:9]=[CH:8][C:7]=2[CH:25]=1)[CH3:2].[CH2:26]([O:28][C:29]([C:31]1[N:32]=[C:33]([CH2:36]Br)[O:34][CH:35]=1)=[O:30])[CH3:27]>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]2[CH:16]([C:17]3[C:18](=[O:24])[NH:19][C:20](=[O:23])[N:21]([CH2:36][C:33]4[O:34][CH:35]=[C:31]([C:29]([O:28][CH2:26][CH3:27])=[O:30])[N:32]=4)[CH:22]=3)[C:11]3[N:12]=[C:13]([CH3:15])[O:14][C:10]=3[CH:9]=[CH:8][C:7]=2[CH:25]=1)[CH3:2]

Komponenten

3

Edukt 2

HCID 641223Ethyl 2-(bromomethyl)-1,3-oxazole-4-carboxylateHCID 70113435(+/-)-5-(7-Ethyl-2-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-2,4(1H,3H)-pyrimidinedione

Produkt 1

HCID 131722508(+/-)-2-[[5-(7-Ethyl-2-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-oxazolecarboxylic acid, ethyl ester

Versuchsvorschrift

The subtitle compound was prepared from the product of example 3 step (vii) (2.2 g) and 2-bromomethyl-4-oxazolecarboxylic acid ethyl ester (0.52 g) using the method of example 1 step (viii). Purification was by chromatography eluting with ethyl acetate.

Aufarbeitung

  1. customPurification
  2. washeluting with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-692a395e00fe4cf4b4e267be5da13ba7
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06218376B1

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