Lawesson's reagent → (+/-)-5-(7-Chloro-2-(pyrrolidin-1-yl)-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-yl)-1-methyl-3,4-dihydro-4-thioxo-2(1H)-pyrimidinone
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:19]([C:20]3[C:21](=O)[NH:22][C:23](=[O:27])[N:24]([CH3:26])[CH:25]=3)[C:10]3[N:11]=[C:12]([N:14]4[CH2:18][CH2:17][CH2:16][CH2:15]4)[S:13][C:9]=3[CH:8]=[CH:7][C:6]=2[CH:29]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:39])=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:19]([C:20]3[C:21](=[S:39])[NH:22][C:23](=[O:27])[N:24]([CH3:26])[CH:25]=3)[C:10]3[N:11]=[C:12]([N:14]4[CH2:18][CH2:17][CH2:16][CH2:15]4)[S:13][C:9]=3[CH:8]=[CH:7][C:6]=2[CH:29]=1Komponenten
3
Versuchsvorschrift
The product from step (i) (0.04 g) was treated with Lawesson's reagent (0.037 g) according to the method of example 34 step (iv). Purification was by chromatography eluting with 1:1 ethyl acetate/isohexane to give the title product as a yellow solid.
Aufarbeitung
- customPurification
- washeluting with 1:1 ethyl acetate/isohexane