Methylenechloride Hexane → HCID 22004872, Verbindung
Reaktionsgleichung
[CH:1]([C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:7]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:6]([CH:24]([CH3:26])[CH3:25])[N:5]=1)([CH3:3])[CH3:2].[CH2:27](Cl)Cl.CCCCCC>>[CH:1]([C:4]1[C:9]([CH:10]([OH:11])[CH3:27])=[C:8]([C:12]2[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=2)[C:7]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:6]([CH:24]([CH3:25])[CH3:26])[N:5]=1)([CH3:3])[CH3:2]Komponenten
3
Versuchsvorschrift
The title compound was prepared from 2,6-diisopropyl-3-hydroxymethyl-4-(4fluorophenyl)-5-pentylpyridine (Example 1) according to the procedures described in Example 101. 1H NMR (300 MHz, CDCl3): δ 7.10 (m, 4 H), 4.65 (dq, J=2.8, 6.6 Hz, 1 H), 3.75 (septet, J=6.6 Hz, 1 H), 3.20 (septet, J=6.6 Hz, 1 H), 2.19 (t, J =8.1 Hz, 2 H), 1.63 (d, J=2.6 Hz, 1 H), 1.40 (d, J=7.0 Hz, 3 H), 1.31 (m, 14 H), 1.11 (m, 4 H), 0.79 (t, J=6.6 Hz, 3 H). FAB-MS: calcd for (C24H34FNO) 371, found 372 (M+H). Anal. Calcd for C24H34FNO: C, 77.59; H, 9.22; N, 3.77; F, 5.11. Found: C, 77.59; H, 9.34; N, 3.75; F, 5.26. mp 99-101° C. Rf=0.2 (70% CH2Cl2/hexane).