Thionyl Chloride → 3-(Chloromethyl)-1,1'-biphenyl

HRID 324970

Reaktionsgleichung

Reaktionsgleichung von HRID 324970
O[CH2:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1.S(Cl)([Cl:17])=O>>[Cl:17][CH2:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 6035563-Biphenylmethanol

Produkt 1

HCID 154808923-(Chloromethyl)-1,1'-biphenyl

Versuchsvorschrift

A solution of 50 mg of 3-hydroxymethylbiphenyl in 1.5 mL thionyl chloride was heated at reflux temperature for 4 hr, cooled to room temperature and the solvent removed by evaporation under reduced pressure to yield 45 mg of 3-chloromethylbiphenyl which was used in the next step without further purification or characterization.

Aufarbeitung

  1. temperatureat reflux temperature for 4 hr
  2. customthe solvent removed by evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9e13e4c29c3e404eb17e55021b1c95f0
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06221871B1

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