HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Amino-o-cresol → 3-t-Butoxycarbonylamino-2-methylphenol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Amino-o-cresol | HCID 104448 | — |
| Edukt | Carbonic acid, bis(1,1-dimethylethyl) ester | HCID 10219638 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 3-t-Butoxycarbonylamino-2-methylphenol | HCID 22033487 | 69% |
Reaktionsschritte
3-Amino-2-methylphenol (2.0 g; 16 mmol) and di-t-butylcarbonate were dissolved in THF (20 mL) and refluxed overnight. Evaporation of the solvent followed by flash chromatography (SiO2; EtOAc 5-30% in isohexane) afforded 2.48 g (69%) of the sub-title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06221898B1 |
| Quelldatensatz | uspto-grants-2001_04 |
| ORD ID | ord-14d40c7fbec645dd81d48e97be74a956 |
| Quellennotiz | uspto-grants-2001_04 |