2-(Diisopropylamino)ethyl chloride → HCID 9892240, Verbindung

HRID 325149Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 325149
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[CH:23][C:12]=3[C:13]=2[C:14](=[O:22])[C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[CH:29]([N:32]([CH2:36][CH2:37]Cl)[CH:33]([CH3:35])[CH3:34])([CH3:31])[CH3:30].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[CH:23][C:12]=3[C:13]=2[C:14](=[O:22])[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:37][CH2:36][N:32]([CH:33]([CH3:35])[CH3:34])[CH:29]([CH3:31])[CH3:30])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 73122-(Diisopropylamino)ethyl chlorideHCID 11430Potassium CarbonateHCID 10044927HCID 10044927, Verbindung

Produkt 1

HCID 9892240HCID 9892240, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

The title compound was prepared by reacting the compound of Preparation 4a supra, 2-(4-methoxyphenyl)-3-(4-hydroxybenzoyl)-6-methoxybenzofuran (10 g, 26.7 mmol) which is dissolved in 200 ml of N,N-dimethylformamide with 2-(N,N-diisopropylamino)ethyl chloride (6.4 g, 32 mmol) and potassium carbonate (11.06 g, 80.2 mmol). The mixture was heated to 100° C. and was maintained at that temperature for about two hours. The reaction mixture was then cooled to room temperature and maintained at this temperature overnight while stirring.

Aufarbeitung

  1. temperaturewas maintained at that temperature for about two hours
  2. temperatureThe reaction mixture was then cooled to room temperature
  3. temperaturemaintained at this temperature overnight

Quellen und Nachweise

ORD-Eintrag
ord-49c6368ea2f7458794f143a0f641742d
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06221838B1

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