Nitrous Acid → Methyl 4-fluoro-2-phenylbenzoate

HRID 325210Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 325210
N[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:3]=1.N([O-])=O.[Na+].N(O)=O.[H+].[B-](F)(F)(F)[F:27]>>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([F:27])=[CH:3][C:4]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

5

Edukt 4

HCID 24529Nitrous AcidHCID 28118Tetrafluoroboric acidHCID 154069885-Amino-biphenyl-2-carboxylic acid methyl esterHCID 23668193Sodium Nitrite

Produkt 1

HCID 54170746Methyl 4-fluoro-2-phenylbenzoate

Versuchsvorschrift

A solution of methyl 4-amino-2-phenylbenzoate (1.0 equivalent) in dilute aqueous HBF4 is treated with NaNO2 (1.1 equivalents) until an excess of nitrous acid persists. The mixture is extracted into ethyl acetate which is dried and evaporated. The title ester is purified by chromatography on silica gel.

Aufarbeitung

  1. extractionThe mixture is extracted into ethyl acetate which
  2. customis dried
  3. customevaporated
  4. customThe title ester is purified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-a59aa93faa34482abdedab2de5b795a3
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06221865B1

Notizen zur Reaktion

Wird geladen…