Tert-butyl 2-(cyclopentylamino)acetate → N-(2-Acetylthio-3-methylbenzoyl)-N-cyclopentylglycine t-butyl ester

HRID 325489Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 325489
[C:1]([O:5][C:6](=[O:14])[CH2:7][NH:8][CH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1)([CH3:4])([CH3:3])[CH3:2].[C:15]([S:18][C:19]1[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][C:20]=1[C:21](O)=[O:22])(=[O:17])[CH3:16]>C(Cl)Cl>[C:1]([O:5][C:6](=[O:14])[CH2:7][N:8]([C:21](=[O:22])[C:20]1[CH:24]=[CH:25][CH:26]=[C:27]([CH3:28])[C:19]=1[S:18][C:15](=[O:17])[CH3:16])[CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13]1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 2

HCID 13298943Tert-butyl 2-(cyclopentylamino)acetateHCID 204652132-Acetylthio-3-methylbenzoic acid

Produkt 1

HCID 20465218N-(2-Acetylthio-3-methylbenzoyl)-N-cyclopentylglycine t-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

N-Cyclopentylglycine t-butyl ester (8.3 g, 0.042 mole) and 2-acetylthio-3-methylbenzoic acid (8.9 g, 0.042 mole) were combined in 90 ml CH2Cl2. This solution was cooled to 0° C. before adding to it a solution of N,N-dicyclohexylcarbodiimide (8.6 g, 0.042 mole) in 30 ml CH2Cl2 dropwise over 15 minutes. The reaction was allowed to warm slowly to room temperature overnight.

Aufarbeitung

  1. temperatureto warm slowly to room temperature overnight

Quellen und Nachweise

ORD-Eintrag
ord-55004cc9fd5d472c8dbaa8bd9cb6e1a1
Quelldatensatz
uspto-grants-1984_04
Patentnummer
US04440941

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