3-Amino-4-methoxy-1,2,5-thiadiazole 1-oxide → HCID 23312508, Verbindung

Reaktionsgleichung

CN(CC1N=C(OCCCN)C=CC=1)C.NC1C(OC)=NS(=O)N=1.[NH2:25][C:26]1[C:30]([NH:31][CH2:32][CH2:33][CH2:34][O:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH2:42][N:43]3[CH2:48]CCC[CH2:44]3)[N:37]=2)=[N:29][S:28](=O)[N:27]=1>>[NH2:25][C:26]1[C:30]([NH:31][CH2:32][CH2:33][CH2:34][O:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH2:42][N:43]([CH3:44])[CH3:48])[N:37]=2)=[N:29][S:28][N:27]=1

Komponenten

Edukt 3

HCID 159612163-Amino-4-methoxy-1,2,5-thiadiazole 1-oxide

HCID 15961340HCID 15961340, Verbindung

HCID 21292013HCID 21292013, Verbindung

Produkt 1

HCID 23312508HCID 23312508, Verbindung

Versuchsvorschrift

When a methanolic solution of 3-(6-dimethylaminomethyl-2-pyridyloxy)propylamine [prepared according to published United Kingdom Patent Application No. 2,098,988] is reacted with 3-amino-4-methoxy-1,2,5-thiadiazole 1-oxide according to the general procedure described in U.S. Pat. No. 4,374,248, PG,42 and the resulting 3-amino-4-[3-(6-piperidinomethyl-2-pyridyloxy)-propylamino]-1,2,5-thiadiazole 1-oxide is reacted according to the general procedure described in Example 3, the title compound is thereby produced.