Timonacic → 3-[3-(4-Pentadecenylamino)benzoyl]-4-carboxythiazolidine

HRID 325570

Reaktionsgleichung

Reaktionsgleichung von HRID 325570
[CH2:1]([NH:16][C:17]1[CH:18]=[C:19]([CH:32]=[CH:33][CH:34]=1)[C:20]([N:22]1[CH:26]([C:27]([O:29]CC)=[O:28])[CH2:25][S:24][CH2:23]1)=[O:21])[CH2:2][CH2:3][CH:4]=[CH:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].S1CC(C(O)=O)NC1>C(=O)(O)[O-].[Na+].CC(C)=O>[CH2:1]([NH:16][C:17]1[CH:18]=[C:19]([CH:32]=[CH:33][CH:34]=1)[C:20]([N:22]1[CH:26]([C:27]([OH:29])=[O:28])[CH2:25][S:24][CH2:23]1)=[O:21])[CH2:2][CH2:3][CH:4]=[CH:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

Komponenten

4

Edukt 2

HCID 9934TimonacicHCID 538623083-[3-(4-Pentadecenylamino)benzoyl]-4-carboethoxythiazolidine

Produkt 1

HCID 537972693-[3-(4-Pentadecenylamino)benzoyl]-4-carboxythiazolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 86737261Acetone sodium bicarbonateLösungsmittel

Versuchsvorschrift

By means of the alkaline hydrolysis method of Example 2 the ethyl ester of Example 548 is converted to the subject carboxylic acid. This acid is also prepared using the procedure of Example 548 except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution.

Aufarbeitung

  1. customThis acid is also prepared

Quellen und Nachweise

ORD-Eintrag
ord-df868f938c0f45f6a856aa523a785110
Quelldatensatz
uspto-grants-1984_04
Patentnummer
US04440940

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