Hydrochloric Acid → 5-(chloromethyl)pyrimidine-2,4(1h,3h)-dione

HRID 325770

Reaktionsgleichung

Reaktionsgleichung von HRID 325770
O[CH2:2][C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1.[ClH:11]>>[Cl:11][CH2:2][C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 781685-(Hydroxymethyl)uracil

Produkt 1

HCID 2361255-(chloromethyl)pyrimidine-2,4(1h,3h)-dione

Versuchsvorschrift

A solution of 1.4 g. (0.010 mole) of 5-hydroxymethyl uracil in 12.5 ml. of concentrated hydrochloric acid was prepared. A colorless precipitate (5-chloromethyl uracil) formed within two minutes and after about ten minutes the precipitate was collected by filtration, washed rapidly with ice cold water, dried and then suspended in 10 ml. of dimethylformamide.

Quellen und Nachweise

ORD-Eintrag
ord-6b035761cb7c49199778fff3e1e35582
Quelldatensatz
uspto-grants-1984_04
Patentnummer
US04442290

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