4-Nitro-1-indanyl acetate → 4-Amino-1-indanyl acetate

HRID 325775Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 325775
[C:1]([O:4][CH:5]1[C:13]2[C:8](=[C:9]([N+:14]([O-])=O)[CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1)(=[O:3])[CH3:2].[H][H]>C(O)C.[Pt]=O>[C:1]([O:4][CH:5]1[C:13]2[C:8](=[C:9]([NH2:14])[CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 131024574-Nitro-1-indanyl acetateHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 131024584-Amino-1-indanyl acetateAusbeute 97,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of 10.0 g (0.045 mole) of 4-nitro-1-indanyl acetate in 200 mL of ethanol was mixed with 0.1 g of platinum oxide in 20 mL of ethanol, and the mixture was contacted with hydrogen in a Parr hydrogenator. Upon complete uptake of hydrogen, the reaction mixture was allowed to stand for 16 hours. The platinum oxide was removed by filtration through diatomaceous earth, and the filter cake was washed with ethanol. The ethanol washings were combined with the filtrate, and the whole was concentrated under reduced pressure to give 8.4 g of 4-amino-1-indanyl acetate as an oil.

Aufarbeitung

  1. customThe platinum oxide was removed by filtration through diatomaceous earth
  2. washthe filter cake was washed with ethanol
  3. concentrationthe whole was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-31bb8b8e52304bd48e4fd3f03e169948
Quelldatensatz
uspto-grants-1984_04
Patentnummer
US04442296

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