Phosphorus oxychloride → 4-Chlorofuro(3,2-d)pyrimidine
Reaktionsgleichung
[N:1]1[C:6]2[CH:7]=[CH:8][O:9][C:5]=2[C:4](=O)[NH:3][CH:2]=1.P(Cl)(Cl)([Cl:13])=O>>[Cl:13][C:4]1[C:5]2[O:9][CH:8]=[CH:7][C:6]=2[N:1]=[CH:2][N:3]=1Komponenten
3
Versuchsvorschrift
Furo[3,2-d]pyrimidin-4(3H)-one (Intermediate 83) (1.49 g) and phosphorus oxychloride (15 mL) were heated to 120° C. for 45 minutes, cooled to ambient temperature, and evaporated under high vacuum. The residue was added to 50% saturated sodium carbonate (100 mL) and extracted into DCM (3×100 mL). The combined organics were dried and the solvent removed to afford the title compound as an orange solid (1.32 g, 78%);
Aufarbeitung
- customevaporated under high vacuum
- additionThe residue was added to 50% saturated sodium carbonate (100 mL)
- extractionextracted into DCM (3×100 mL)
- customThe combined organics were dried
- customthe solvent removed
Quellen und Nachweise
- ORD-Eintrag
- ord-8db1e40577c04faa9c33e5c9eadfec9b
- Quelldatensatz
- uspto-grants-2008_09
- Patentnummer
- US07427616B2
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