1-Chloro-2-(diethylamine)ethane hydrochloride → 2-(2-{[2-(Dimethylamino)ethyl]thio}-1-methyl-4-phenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine

HRID 32610

Reaktionsgleichung

Reaktionsgleichung von HRID 32610
[NH2:1][C:2]1[C:3]2[N:10]=[C:9]([C:11]3[N:15]([CH3:16])[C:14]([SH:17])=[N:13][C:12]=3[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[S:8][C:4]=2[N:5]=[CH:6][N:7]=1.Cl.[CH2:25]([N:27]([CH2:30]CCl)[CH2:28]C)[CH3:26].[OH-].[Na+]>>[CH3:28][N:27]([CH3:30])[CH2:25][CH2:26][S:17][C:14]1[N:15]([CH3:16])[C:11]([C:9]2[S:8][C:4]3[N:5]=[CH:6][N:7]=[C:2]([NH2:1])[C:3]=3[N:10]=2)=[C:12]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:13]=1

Komponenten

4

Edukt 3

HCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 14798Sodium HydroxideHCID 178481673HCID 178481673, Verbindung2×

Produkt 1

HCID 104767412-(2-{[2-(Dimethylamino)ethyl]thio}-1-methyl-4-phenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazole-2-thiol (Intermediate 47) (10 mg), N,N-diethyl-2-chloroethylamine hydrochloride (9 mg) and 2M NaOH (1 mL) was heated at 60° C. for 6 hours. After which the reaction mixture was cooled to ambient temperature and the title compound isolated by filtration as a yellow solid (6 mg, 50%);

Aufarbeitung

  1. temperatureAfter which the reaction mixture was cooled to ambient temperature

Quellen und Nachweise

ORD-Eintrag
ord-fac9286b65b842e4b6bda091b4d6796d
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07427616B2

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