Benzyl Chloride → Benzyl 4-methyl-2-oxopentanoate

HRID 326377

Reaktionsgleichung

Reaktionsgleichung von HRID 326377
[Na+].[O:2]=[C:3]([CH2:7][CH:8]([CH3:10])[CH3:9])[C:4]([O-:6])=[O:5].[CH2:11](Cl)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CN(C=O)C.C(Cl)(Cl)Cl>[CH3:9][CH:8]([CH3:10])[CH2:7][C:3](=[O:2])[C:4]([O:6][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5]

Komponenten

5

Edukt 2

HCID 7503Benzyl ChlorideHCID 4137900Sodium 4-methyl-2-oxovalerate

Produkt 1

HCID 4072499Benzyl 4-methyl-2-oxopentanoateAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6212ChloroformLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 2-Oxo-4-methyl pentanoic acid sodium salt (10 g, 65.7 mmol) and benzyl chloride (8 g, 63 mmol) in 300 ml DMF was stirred at 40°-50° C. for 5 h. It was filtered, and the filtrate was evaporated under reduced pressure to provide an oil. The oil was dissolved in chloroform, washed with water, dried, filtered, and evaporated to provide the desired product (13 g, 94%). 1H NMR (CDCl3, TMS) δ0.95 (d,6H), 2.15 (m,1H), 2.7 (d,2H), 5.28 (s,2H), 7.4 (m,5H). Mass spectrum: (M+H)+ =221.

Aufarbeitung

  1. filtrationIt was filtered
  2. customthe filtrate was evaporated under reduced pressure
  3. customto provide an oil
  4. washwashed with water
  5. customdried
  6. filtrationfiltered
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-17556ae88132457880ffb3476e669674
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05268374

Verknüpfte Notizen

Wird geladen…