Thionyl Chloride → 2-Morpholin-4-yl-5-nitro-benzoyl chloride

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a suspension of 2-Morpholin-4-yl-5-nitro-benzoic acid (4.0 g, 16 mmol) in toluene were added 2 drops of DMF and thionylchloride (5.7 ml, 79.3 mmol). The mixture was heated to 80° C. for 50 minutes. The solvent was removed in vacuo, and the resulting solid was stirred in ether, filtered and dried to provide the title compound (4.0 g, 93%) as a yellow solid.

Herkunft & Nachweise