Sodium Hydroxide → HCID 14842739, Verbindung

HRID 326649Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 326649
[I:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:18])[CH:5]=[C:6]([C:13]([O:15]CC)=[O:14])[NH:7]2.IC1C=C2C(C(=O)C=C(C(OCC)=O)N2)=C(C)C=1.[OH-].[Na+]>>[I:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:18])[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[NH:7]2

Komponenten

4

Edukt 3

HCID 14798Sodium HydroxideHCID 19735205HCID 19735205, VerbindungHCID 19735208HCID 19735208, Verbindung

Produkt 1

HCID 14842739HCID 14842739, Verbindung

Versuchsvorschrift

Treatment of a mixture of ethyl 5-iodo-7-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylate and ethyl 7-iodo-5-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylate (0.449 g) with sodium hydroxide (0.20 g) as described in Example 1c gave a mixture of the corresponding carboxylic acids. Chromatography of this mixture (0.220 g) on a reverse phase carbon-18 column gave 5-iodo-7-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (12 mg), mp 306° C. δ (360 MHz, DMSO-d6) 2.33 (3H, s, CH3), 6.55 (1H, s, 3-H) and 7.75 (2H, bs, 6-H and 8-H).

Aufarbeitung

  1. customgave

Quellen und Nachweise

ORD-Eintrag
ord-a696a987d30d4ea8bf14647cb2c2d3c4
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05270309

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