Formamidine → 5-(o-chlorobenzyl)-6-hydroxy-4(3H)-pyrimidinone
Reaktionsgleichung
[Cl:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[CH2:4][CH:5]([C:11](OCC)=[O:12])[C:6](OCC)=[O:7].[CH:20]([NH2:22])=[NH:21]>>[Cl:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[CH2:4][C:5]1[C:11](=[O:12])[NH:22][CH:20]=[N:21][C:6]=1[OH:7]Komponenten
3
Versuchsvorschrift
Condensation of diethyl o-chlorobenzylmalonate with formamidine yielded 5-(o-chlorobenzyl)-6-hydroxy-4(3H)-pyrimidinone which, by reaction with phosphorus oxychloride, yielded 4,6-chloro-5-(o-chlorobenzyl)pyrimidine, melting point 110°-112° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-938cb0896f2a4a44bf376abc087d4d14
- Quelldatensatz
- uspto-grants-1993_12
- Patentnummer
- US05270313
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