4-Methylbenzylamine → N-cyano-N'-(4-methylbenzyl)-2-pyridinecarboximidamide

HRID 327091

Reaktionsgleichung

Reaktionsgleichung von HRID 327091
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[CH3:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][NH2:19])=[CH:16][CH:15]=1>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:19][CH2:18][C:17]1[CH:20]=[CH:21][C:14]([CH3:13])=[CH:15][CH:16]=1)#[N:2]

Komponenten

4

Edukt 2

HCID 660354-MethylbenzylamineHCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

Produkt 1

HCID 19734553N-cyano-N'-(4-methylbenzyl)-2-pyridinecarboximidamideAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl N-cyano-2-pyridinecarboximidate (0.30 g, 1.9 mmol) was dissolved in methanol (10 ml), p-methylbenzylamine (0.25 g, 2.1 mmol) was added, and the resulting mixture was stirred at room temperature for 2 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from diethyl ether to give the title compound (0.41 g, 1.6 mmol, yield: 91%) as colorless crystals.

Aufarbeitung

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-2389de824a604b57bd0ed45a0c64654a
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05272164

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