4-Chlorobenzylamine → N-cyano-N'-(4-chlorobenzyl)-2-pyridinecarboximidamide

HRID 327092

Reaktionsgleichung

Reaktionsgleichung von HRID 327092
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[Cl:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][NH2:19])=[CH:16][CH:15]=1>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:19][CH2:18][C:17]1[CH:20]=[CH:21][C:14]([Cl:13])=[CH:15][CH:16]=1)#[N:2]

Komponenten

4

Edukt 2

HCID 660364-ChlorobenzylamineHCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

Produkt 1

HCID 19734551N-cyano-N'-(4-chlorobenzyl)-2-pyridinecarboximidamideAusbeute 16,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl N-cyano-2-pyridinecarboximidate (0.50 g, 3.1 mmol) was dissolved in methanol (10 ml), 4-chlorobenzylamine (0.48 g, 3.4 mmol) was added, and the resulting mixture was stirred at room temperature for 5 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from diethyl ether to give the title compound (0.13 g, 0.5 mmol, yield: 16%) as colorless crystals.

Aufarbeitung

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-1bbfd302da1e4f7b950993b809a51943
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05272164

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