4-(Trifluoromethyl)benzylamine → N-cyano-N'-[4-(trifluoromethyl)benzyl]-2-pyridinecarboximidamide

HRID 327093Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 327093
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[F:13][C:14]([F:24])([F:23])[C:15]1[CH:22]=[CH:21][C:18]([CH2:19][NH2:20])=[CH:17][CH:16]=1>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:20][CH2:19][C:18]1[CH:17]=[CH:16][C:15]([C:14]([F:13])([F:23])[F:24])=[CH:22][CH:21]=1)#[N:2]

Komponenten

4

Edukt 2

HCID 768044-(Trifluoromethyl)benzylamineHCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

Produkt 1

HCID 19734571N-cyano-N'-[4-(trifluoromethyl)benzyl]-2-pyridinecarboximidamideAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl N-cyano-2-pyridinecarboximidate (0.36 g, 1.9 mmol) was dissolved in methanol (10 ml), 4-(trifluoromethyl)benzylamine (0.36 g, 2.1 mmol) was added, and the resulting mixture was stirred at room temperature for 30 minutes. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from diethyl ether to give the title compound (0.47 g, 1.5 mmol, yield: 84%) as colorless crystals.

Aufarbeitung

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-39ebf4d5885c43cdb57f052a25e60151
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05272164

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